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Reference type: Journal
Authors: Zulfiqar A, Morgan G, Turner NW
Article Title: Detection of multiple steroidal compounds in synthetic urine using comprehensive gas chromatography-mass spectrometry (GC x GC-MS) combined with a molecularly imprinted polymer clean-up protocol.
Publication date: 2014
Journal: Analyst
Volume: 139
Issue: (19)
Page numbers: 4955-4963.
DOI: 10.1039/C4AN00721B

Abstract: A method capable of screening for multiple steroids in urine has been developed, using a series of twelve structurally similar, and commercially relevant compounds as target analytes. A molecularly imprinted solid phase extraction clean-up step was used to make the sample suitable for injection onto a GC x GC-MS setup. Significant improvements compared to a commercially available C-18 material were observed. Each individual steroid was able to be separated and identified, using both the retention profile and diagnostic fragmentation ion monitoring abilities of the comprehensive chromatographic-mass spectrometry method. Effective LODs of between 11.7 and 27.0 pg were calculated for individual steroids, effectively equivalent to concentration levels of between 0.234 and 0.540 ng mL-1 in urine, while the application of multiple screen was demonstrated using a 10 ng mL-1 mixed sample. The nature of this study also removes the need for sample derivitisation which speeds up the screening process
Template and target information: steroids, 5(10)-estrene-3β,17β-diol, 4-estrene-3β,17β-diol, 5(10)-estrene-3,17-dione, 4-androstene-3β,17β-diol, dhea, 5(6)-androsten-3β-ol-17-one, 5(6)-androstene-3β,17β-diol, 5α-androstane-3,17-diol, 5α-androstane-3,17-dione, nandrolone, 17β-hydroxyestra-4-en-3-one, 5(6)-androstene-3,17-dione, testosterone, 4-androstene-17β-ol-3-one, boldione, 1,4-androstadiene-3,17-dione


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