MIPs logo MIPdatabase      MIP2024 Conference banner, website is now open, register on site for important updates   
Custom Search
Reference type: Journal
Authors: Azodi-Deilami S, Abdouss M, Asadi E, Najafabadi AH, Sadeghi S, Farzaneh S, Asadi S
Article Title: Magnetic molecularly imprinted polymer nanoparticles coupled with high performance liquid chromatography for solid-phase extraction of carvedilol in serum samples.
Publication date: 2014
Journal: Journal of Applied Polymer Science
Volume: 131
Issue: (23)
Page numbers: Article No 41209.
DOI: 10.1002/app.41209

Abstract: Herein, we report a magnetic molecularly imprinted polymers (m-MIPs) using Fe3O4 as a magnetic component, carvedilol as a template molecule for the solid-phase extraction (MISPE) as the sample clean-up technique combined with high-performance liquid chromatography (HPLC) and for the controlled release of carvedilol at different pH values of 1.0 (simulated gastric fluid), 6.8 (simulated intestinal fluid), and 7.4 (simulated biological fluid). The adsorption kinetics was modeled with the pseudo-first-order and pseudo-second-order kinetics, and the adsorption isotherms were fitted with Langmuir and Freundlich models. The performance of the m-MIPs for the controlled release of carvedilol was assessed and results indicated that the magnetic MIPs also have potential applications in controlled drug release. Furthermore, the m-MIPs were applied to the extraction of carvedilol from human blood plasma samples. Carvedilol can be quantified by this method in the 2-350 μg L-1 concentration range. The limit of detection and limit of quantification in plasma samples are 0.13 and 0.45 μg L-1. The results from HPLC showed good precision (3.5% for 50.0 μg L-1) and recoveries (between 85 and 93) using m-MIP from human plasma samples. 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41209
Template and target information: carvedilol
Author keywords: adsorption isotherms and kinetics, high performance liquid chromatography, Magnetic molecularly imprinted polymers, nanostructured polymers, solid phase extraction

  Mister Benzene Comic Strip greetings card  Chemistry peptide mug  Beach bunny periodic table shirt


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner