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Reference type: Journal
Authors: Niu YL, Ma MH, Gong YR, Wang Y, Gong BL
Article Title: Synthesis of chlorogenic acid imprinted chromatographic packing by surface-initiated atom transfer radical polymerization and its application.
Publication date: 2014
Journal: Chemical Research in Chinese Universities
Volume: 30
Issue: (5)
Page numbers: 855-862.
DOI: 10.1007/s40242-014-4201-0

Abstract: A novel chromatographic packing of chlorogenic acid(CGA) molecularly imprinted polymer(MIP) based on the 5.0 μm silica was prepared by surface initiated atom transfer radical polymerization(SI-ATRP) with 4-vinylpyridine(4-VP) as functional monomer, ethyl glycol dimethacrylate(EDMA) as cross-linker in the mixture of methanol and water(7:3, volume ratio) under mild reaction conditions. The characteristics of CGA MIP were investigated by elemental analysis, thermogravimetric analysis(TGA), Fourier transform infrared spectrometry(FTIR) and atomic force microscopy(AFM). The effects of some chromatographic conditions such as mobile phase composition and temperature on the retention time were investigated. The adsorption capacity of the stationary phase for compounds was determined by frontal chromatographic technique. The results show that Freundlich isotherm fits the experimental adsorption isotherm data better than Langmuir model does. The relatively high heterogeneity index values regressed with the Freundlich isotherm suggest the formation of fairly homogeneous MIP. Thermodynamic data(++H and ++S) obtained by van't Hoff plots reveal an entropy-controlled separation. The CGA MIP column was shown to be successful for the separation and purification of chlorogenic acid from the extract of Honeysuckle
Template and target information: chlorogenic acid, CGA
Author keywords: Molecularly imprinted chromatographic packing, chlorogenic acid, Surface initiated atom transfer radical polymerization, Honeysuckle

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