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Reference type: Journal
Authors: Malm B, Yoshimatsu K, Ye L, Krozer A
Article Title: Characterization of molecularly imprinted polymer nanoparticles by photon correlation spectroscopy.
Publication date: 2014
Journal: Journal of Molecular Recognition
Volume: 27
Issue: (12)
Page numbers: 714-721.
DOI: 10.1002/jmr.2397

Abstract: We follow template-binding induced aggregation of nanoparticles enantioselectively imprinted against (S)-propranolol, and the non-imprinted ones, using photon correlation spectroscopy (dynamic light scattering). The method requires no separation steps. We have characterized binding of (R,S)-propranolol to the imprinted polymers and determined the degree of non-specificity by comparing the specific binding with the results obtained using non-imprinted nanoparticles. Using (S)-propranolol as a template for binding to (S)-imprinted nanoparticle, and (R)-propranolol as a non-specific control, we have determined range of concentrations where chiral recognition can be observed. By studying aggregation induced by three analytes related to propranolol, atenolol, betaxolol, and 1-amino-3-(naphthalen-1-yloxy)propan-2-ol, we were able to determine which parts of the template are involved in the specific binding, discuss several details of specific adsorption, and the structure of the imprinted site. Copyright 2014 John Wiley & Sons, Ltd
Template and target information: propranolol, (S)-propranolol
Author keywords: Molecularly imprinted polymers, Brownian motion, chiral selectivity, aggregation kinetics, colloidal suspension


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