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Reference type: Journal
Authors: El Gohary NA, Madbouly A, El Nashar RM, Mizaikoff B
Article Title: Synthesis and application of a molecularly imprinted polymer for the voltammetric determination of famciclovir.
Publication date: 2015
Journal: Biosensors and Bioelectronics
Volume: 65
Page numbers: 108-114.
DOI: 10.1016/j.bios.2014.10.024
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566314008227

Abstract: A molecularly imprinted polymer (MIP) was synthesized and applied as additive within a carbon paste electrode for the cyclic voltammetric determination of famciclovir (FCV). Complementary computational studies were performed to study the intermolecular interactions in the pre-polymerization mixture. Derived from the computational studies, four MIP ratios were synthesized and their performance was evaluated using equilibrium rebinding assays. The MIP with the highest binding capacity was selected. A linear response was obtained in the range of 2.5 x 10-6 - 1.0 x 10-3 M with a limit of detection at 7.5 x 10-7 M. Finally, the developed MIP-voltammetry system was successfully applied for the determination of FCV in pure solutions and pharmaceutical preparations
Template and target information: famciclovir, FCV
Author keywords: molecular imprinted polymers, MIPs, Famciclovir, Computational studies, carbon paste electrode, and cyclic voltammetry


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