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Reference type: Journal
Authors: Xie LW, Li SX, Yu R, Ouyang W, Huang D
Article Title: Simultaneous determination of gallic and protocatechuic acids in Lycium chinense using HPLC coupled with magnetic molecular-imprinted solid phase extraction.
Publication date: 2014
Journal: European Journal of Integrative Medicine
Volume: 6
Issue: (6)
Page numbers: 718.
Alternative URL: http://www.sciencedirect.com/science/article/pii/S1876382014002376

Abstract: Introduction: Gallic acid (GA) and protocatechuic acid (PA) from Lycium chinense exhibit many bioactivities. Due to low content and strong polarity, it is vital to develop a sensitive, simple and rapid method to monitor these polyphenolic compounds from complex matrices, especially using novel adsorption materials for selective extracting target components. Methods: Magnetic molecular-imprinted polymers (MMIPs) were prepared to selectively extract GA and PA from Lycium chinense. The MMIPs were characterized by TEM, FT-IR, TGA and VSM, and evaluated by adsorption isotherms and kinetics, competitive adsorption, and reusability analysis. Results: The adsorption process between GA, PA and MMIPs followed Langmuir adsorption isotherm with maximum adsorption capacity at 60.3 mg/g and 7.5 mg/g, respectively. The prepared MMIPs also showed rapid magnetic separation (10 s) and reusability (retained 95.2% after six cycles). Conclusions: MMIPs could be successfully applied for selective enrichment and determination of GA and PA from Lycium chinense with 2.26 μg/mg GA and 0.76 μg/mg PA in fruits while only 0.31 μg/mg GA and 0.05 μg/mg PA in root bark. Two advantages (Fe3O4 core for quick separation, and surface imprinting MIPs for enough recognition sites and fast binding kinetics) were combined for simple, fast, efficient and selective extraction of GA and PA from Lycium chinense before HPLC analysis
Template and target information: gallic acid, GA, protocatechuic acid, PA

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