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Reference type: Journal
Authors: Qader AA, Urraca J, Torsetnes SB, Tønnesen F, Reubsaet L, Sellergren B
Article Title: Peptide imprinted receptors for the determination of the small cell lung cancer associated biomarker progastrin releasing peptide.
Publication date: 2014
Journal: Journal of Chromatography A
Volume: 1370
Page numbers: 56-62.
DOI: 10.1016/j.chroma.2014.10.023
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0021967314015878

Abstract: Peptide imprinted polymers were developed for detection of progastrin releasing peptide (ProGRP); a low abundant blood based biomarker for small cell lung cancer. The polymers targeted the proteotypic nona-peptide sequence NLLGLIEAK and were used for selective enrichment of the proteotypic peptide prior to LCMS based quantification. Peptide imprinted polymers with the best affinity characteristics were first identified from a 96-polymer combinatorial library. The effects of functional monomers, crosslinker, porogen, and template on adsorption capacity and selectivity for NLLGLIEAK were investigated and optimized. Ultimately, a solid phase extraction method was developed for highly selective enrichment of the target peptide from tryptic digests
Template and target information: peptide, progastrin releasing peptide, ProGRP, NLLGLIEAK
Author keywords: Molecularly imprinted polymers, MIP, solid phase extraction, Combinatorial synthesis


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