MIPs logo MIPdatabase      MIP2024 Conference banner, website is now open, register on site for important updates   
Custom Search
Reference type: Journal
Authors: Du CB, Hu XL, Guan P, Guo LX, Qian LW, Li J, Song RY, Tang YM
Article Title: Synthesis of water-compatible surface-imprinted composite microspheres with core-shell structure for selective recognition of thymopentin from aqueous solution.
Publication date: 2015
Journal: Journal of Materials Science
Volume: 50
Issue: (1)
Page numbers: 427-438.
DOI: 10.1007/s10853-014-8602-8

Abstract: A novel water-compatible surface-imprinted core-shell microsphere, which had multiple non-covalent interactions with template molecule, was successfully prepared by the surface grafting polymerization method in acetonitrile-water systems with thymopentin as template through ionic liquid-functionalized polyethyleneglycolmethacrylate-co-vinylimidazole microsphere as the matrix. The average diameter of matrix was 1 μm 20 nm and the thickness of imprinted layer was about 50 nm. The results of static adsorption experiments indicated that ionic liquid-functionalized molecularly imprinted microspheres showed the good adsorption capacity and specific recognition for template peptide. The binding-isotherm analysis showed that Langmuir isotherm models gave a good fit in the range of concentrations, suggesting that there was only one kind of binding site in imprinted layer. Measurements of the binding kinetics revealed that surface-imprinted composite microspheres reached peptide-adsorption equilibrium in 60 min and the maximum adsorption capacity for TP5 was 38.4 mg g-1. The effects of pH, salt concentration, and temperature on the adsorption capacities were investigated. The microspheres were found to have a high specificity for TP5 with little affinity for BSA and Hb. Finally, the core-shell microspheres can be reused with only 15.6 % decrease in TP5 adsorption capacity after six times
Template and target information: thymopentin, peptide, TP5

  mipdatabase.com logo special offer joke shirt  Lab Hero Periodic tablemug  HE-MAN polymer chemistry shirt


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner