Abstract: To improve the sensitivity, a CuO nanoparticle doped in molecularly imprinted polymer (MIP) film for the determination of phenobarbital was prepared by using methacrylic acid as functional monomers, ethylene glycol maleic rosinate acrylate as a cross linking agent by thermal polymerization method. The electrochemical properties of the nano-doped sensor were investigated using cyclic voltammetry (CV), differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS) and chrono-amperometry (CA). The chemical structures and morphologies of the imprinted films were characterized using Fourier transform infrared spectroscopy and scanning electron microscopy. The results indicated that the sensors response value of peak current showed a linear dependence on the phenobarbital concentration in the ranges of 1.2 x 10-7 - 1.5 x 10-4 mol/L of phenobarbital. (Linear regression coefficient=0.9984) with the detection limit (S/N=3) of 8.2 x 10-9 mmol/L. The prepared sensor was successfully applied to the determination of phenobarbital in practical samples with recovery ranging from 96.5% to 103.0%.
Template and target information: phenobarbital
Author keywords: Copper oxide nanoparticles, phenobarbital, ethylene glycol maleic rosinate acrylate, Molecular polymer imprinted