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Reference type: Journal
Authors: Wang CQ, Bai HP, Chen J, Cao QE
Article Title: Preparation and Application of Podophyllotoxin Sensor Based on Molecularly Imprinting Technique.
Publication date: 2014
Journal: Chinese Journal of Analytical Chemistry
Volume: 42
Issue: (6)
Page numbers: 842-846.
DOI: 10.3724/SP.J.1096.2014.40017
Alternative URL:

Abstract: A novel electrochemical sensor for the determination of podophyllotoxin (PPT) was prepared by modifying a PPT-imprinted membrane, which was synthesized by in situ polymerization with PPT as template, methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross linking agent at the molar ratio of PPT/MAA/EGDMA as 1:2:100, on glassy carbon electrode (GCE) followed by eluting PPT from the modified GCE with methanol/acetic acid (1:1, V/V). The properties of the electrochemical sensor modified with PPT-imprinted membrane were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS). Under the optimum conditions, it was found that the response of peak currents was linear to the concentration of PPT in range of 1.0-120 μmol/L with the detection limit of 0.47 μmol/L. The sensor not only showed high selectivity, but also exhibited good stability and reproducibility. The sensor was satisfactorily applied to the determination of PPT in podophyllum hexandrum and human serum samples with the relative standard deviation (RSD) below 3.9% and recovery ranging from 95.0% to 103.3%.
Template and target information: podophyllotoxin, PPT
Author keywords: Podophyllotoxin, molecularly imprinted membrane, Electrochemical sensor, In situ polymerization

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