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Reference type: Journal
Authors: Hou S, Wang YF, Liu N, Liu J
Article Title: Preparation and Recognition Characteristics of Thymopentin Molecularly Imprinted Polymers on SiO2.
Publication date: 2014
Journal: Adsorption Science & Technology
Volume: 32
Issue: (10)
Page numbers: 833-844.
DOI: 10.1260/0263-6174.32.10.833
Alternative URL: http://journals.sagepub.com/doi/abs/10.1260/0263-6174.32.10.833

Abstract: A computer simulation approach was developed to screen functional monomers for the rational design of molecularly imprinted polymers (MIPs). The proposed approach is based on a comparison of the binding energy of complexes, which are formed by the interaction between a template molecule and various functional monomers. According to the results of theoretical calculations, MIPs using thymopentin (TP5) as a template were prepared by a solution polymerization method, in which 2-methylacrylamide, N,N'-methylenebisacrylamide and poly(methylacrylic acid)/SiO2 were used as the functional monomer, cross-linker and support, respectively. Solid-phase extraction experiments were performed, and static and dynamic binding properties of the synthesized MIP (i.e. TP5-MIP) for TP5 were studied. Results show that TP5-MIP exhibits excellent binding affinity and specific selectivity for the template molecule (i.e. TP5)
Template and target information: thymopentin, TP5

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