MIPs logo MIPdatabase    HoHoHo MIP2018 Conference website
Custom Search
Reference type: Journal
Authors: Du CB, Hu XL, Guan P, Guo LX, Qian LW, Song RY, Li J, Wang CL
Article Title: Water-compatible surface-imprinted microspheres for high adsorption and selective recognition of peptide drug from aqueous media.
Publication date: 2015
Journal: Journal of Materials Chemistry B
Volume: 3
Issue: (15)
Page numbers: 3044-3053.
DOI: 10.1039/C4TB02030H

Abstract: Novel water-compatible ionic liquid-functionalized microspheres with molecularly imprinted shell layer were controllably synthesized via precipitation polymerization and surface imprinting technique. Here, a room-temperature ionic liquid was synthesized to prepare these surface-imprinted microspheres with excellent water solubility and multiple binding sites with template molecules. The peptide drug thymopentin (TP5) was chosen as a template molecule, which is known as an immunomodulating agent. The as-prepared microspheres were fully characterized. Results reveal that ionic liquid incorporation significantly improves the adsorption of TP5. Moreover, the adsorption property and recognition capability towards TP5 are closely related to the synergetic effect of electrostatic interaction and hydrogen bonding. Through employing the synergetic effect of directional and non-directional interactions, the surface-imprinted microspheres exhibit high adsorption capacity, good selective recognition, and rapid binding ability for TP5. The surface-imprinted microspheres demonstrate potential usage for TP5 enrichment from other biomolecules, and the proposed method was successfully applied for TP5 determination in thymopentin injection and urine
Template and target information: peptide, thymopentin, TP5


  mipdatabase.com logo special offer joke shirt  Mug featuring the name PeptideChemist spelled out in the single letter amino acid code  HE-MAN polymer chemistry shirt

Molecules Special Issue call     Sensors Special Issue call






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon