MIPs logo MIPdatabase     MIP2018 Conference website
Custom Search
Reference type: Journal
Authors: Dima SO, Nicolae CA, Iordache TV, Chetraru O, Meouche W, Faraon VA, Donescu D
Article Title: Thermal analyses as tools for proving the molecular imprinting with diosgenin and sclareol in acrylic copolymer matrices.
Publication date: 2015
Journal: Journal of Thermal Analysis and Calorimetry
Volume: 120
Issue: (2)
Page numbers: 1107-1118.
DOI: 10.1007/s10973-015-4455-x

Abstract: Thermogravimetric analysis (TG), derivative thermogravimetry (DTG), differential scanning calorimetry (DSC), dynamic mechanical thermal analysis, simultaneous differential thermogravimetry (SDT) coupled with mass spectrometry (MS), and pyrolysis coupled with gas chromatography/mass spectrometry (Py-GC/MS) were used to characterize molecularly imprinted polymers (MIPs) obtained with two anti-cancerous template molecules, diosgenin and sclareol, imprinted in acrylonitrile-acrylic acid copolymer matrices. First of all, TG analyses revealed a specific mass loss in the temperature range 220-300 C characteristic to diosgenin-MIPs, while for the sclareol-MIPs, the specific interval was 100-240 C. Further, the DSC analyses evidenced two major aspects: first, that the copolymer matrices have a single glass transition temperature (T g), which confirms the random statistic copolymer structure, an essential characteristic of a homogenous MIP matrix; secondly, both templates influence the T g values of the MIPs, fact that is an additional proof of molecular imprinting. The SDT results confirmed the TG and DSC results and, additionally, proved that the system with higher acrylic acid content generates stronger template-matrix interactions via hydrogen, van der Waals, and other non-covalent forces, fact that appears as an increased thermal stability on the TG curve and a higher maximum for template decomposition on the DTG curve. The MS results evidenced that a single mass fragment, 139 1 m/z, characteristic for the class of steroid sapogenines of which diosgenin belongs, is enough to prove, qualitatively and quantitatively, the molecular imprinting and the template elution. As global conclusion, the applied thermal analyses proved to be exceptional tools for analyzing these molecularly imprinted polymers
Template and target information: diosgenin, sclareol
Author keywords: Thermal analysis, Molecularly imprinted polymers, Pyrolysis, mass spectrometry, Diosgenin, Sclareol


  mipdatabase.com logo imprinters do it in bulk shirt  Science Teacher peptide mug  Perpetual student shirt

Molecules Special Issue call     Sensors Special Issue call






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon