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Reference type: Journal
Authors: Zhang Y, Deng CY, Liu S, Wu J, Chen ZB, Li C, Lu WY
Article Title: Active Targeting of Tumors through Conformational Epitope Imprinting.
Publication date: 2015
Journal: Angewandte Chemie International Edition
Volume: 54
Issue: (17)
Page numbers: 5157-5160.
DOI: 10.1002/anie.201412114

Abstract: Inspired by the knowledge that most antibodies recognize a conformational epitope because of the epitope's specific three-dimensional shape rather than its linear structure, we combined scaffold-based peptide design and surface molecular imprinting to fabricate a novel nanocarrier harboring stable binding sites that captures a membrane protein. In this study, a disulfide-linked α-helix-containing peptide, apamin, was used to mimic the extracellular, structured N-terminal part of the protein p32 and then serve as an imprinting template for generating a sub-40 nm-sized polymeric nanoparticle that potently binds to the target protein, recognizes p32-positive tumor cells, and successfully mediates targeted photodynamic therapy in vivo. This could provide a promising alternative for currently used peptide-modified nanocarriers and may have a broad impact on the development of polymeric nanoparticle-based therapies for a wide range of human diseases
Template and target information: peptide, apamin, p32 protein, protein, tumor cell
Author keywords: conformational epitopes, drug delivery, imprinting, photodynamic therapy, tumor targeting


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