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Reference type: Journal
Authors: Saad EM, Madbouly A, Ayoub N, El Nashar RM
Article Title: Preparation and application of molecularly imprinted polymer for isolation of chicoric acid from Chicorium intybus L. medicinal plant.
Publication date: 2015
Journal: Analytica Chimica Acta
Volume: 877
Page numbers: 80-89.
DOI: 10.1016/j.aca.2015.03.047
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0003267015004389

Abstract: Molecularly imprinted polymer (MIP) was synthesized and applied for the extraction of chicoric acid from Chicory herb (Chicorium intybus L.). A computational study was developed to find a suitable template to functional monomer molar ratio for MIP preparations. The molar ratio was chosen based on the comparison of the binding energy of the complexes between the template and functional monomers. Based on the computational results, eight different polymers were prepared using chicoric acid as the template. The MIPs were synthesized in a non-covalent approach via thermal free-radical polymerization, using two different polymerization methods, bulk and suspension. Batch rebinding experiments were performed to evaluate the binding properties of the imprinted polymers. The best results were obtained with a MIP prepared using bulk polymerization with 4-vinylpyridine (4-VP) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker with a molar ratio of 1:4:20. The best MIP showed selective binding ability toward chicoric acid in the presence of the template's structural analogues, caffeic acid, caftaric acid and chlorogenic acid
Template and target information: chicoric acid
Author keywords: molecularly imprinted polymer, Computational study, extraction, Phenolic acids, Chicoric acid


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