MIPs logo MIPdatabase     MIP2018 Conference website
Custom Search
Reference type: Journal
Authors: Latorre AL, Cela Pérez MC, Fernández Fernández S, López Vilarińo JM, González Rodríguez MV
Article Title: Selective removal of ATP degradation products from food matrices I: Design and characterization of a dummy molecularly imprinted specific sorbent for hypoxanthine.
Publication date: 2015
Journal: Reactive and Functional Polymers
Volume: 91-92
Page numbers: 51-61.
DOI: 10.1016/j.reactfunctpolym.2015.04.004
Alternative URL: http://www.sciencedirect.com/science/article/pii/S1381514815000590

Abstract: Specific molecularly imprinted polymers (MIPs) for hypoxanthine (HYP) recognition in aqueous organic media have been developed based upon UV, FTIR and 1H NMR prepolymerization studies in conjunction with batch rebinding UPLC analyzes. The MIPs, which used the template mimics caffeine (CAF) and theophylline (TPH), are prepared in CHCl3 by one step precipitation polymerization from acrylamide (AM), 2-hydroxyethyl-methacrylate (HEMA) and methacrylic acid (MAA) as functional monomers, whereas ethylene glycol dimethacrylate (EGDMA), divinylbenzene (DVB) and trimethylolpropane triacrylate (TMPTA) as cross-linkers. The magnitude of the pre-polymerization binding constants between TPH and AM, MAA and HEMA is consistent with the complex stoichiometry (1:2 and 1:1) and number of interaction points (3-, 2-, 1-hydrogen bonded motif). The strong (1:2) complex between TPH and AM (K11 = 3.36 x 104 M-1 and K12 = 1.33 x 102 M-1) makes the corresponding MIP the most suitable for HYP recognition. The best performance of the TPH:AM:EGDMA (1:4:20) MIP is reflected in the high IF and high weighted average affinity based on the Freundlich isotherm. Further polymer characterization by ATR-FTIR, elemental analysis, surface area analysis (BET), swelling and SEM yield vital information regarding the degree of polymerization, real monomer:crosslinker ratio, morphology, pore size distribution plus conformational changes on exposure to different solvents
Template and target information: hypoxanthine, HYP, template mimics, caffeine, CAF, theophylline, TPH
Author keywords: hypoxanthine, molecular imprinting, Dummy-template, spectroscopy, morphology


  Periodic table Trainer shirt  PhD Scientist peptide mug    Mug featuring the template Theophylline

Molecules Special Issue call     Sensors Special Issue call






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon