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Reference type: Journal
Authors: Miura C, Li H, Matsunaga H, Haginaka J
Article Title: Molecularly imprinted polymer for chlorogenic acid by modified precipitation polymerization and its application to extraction of chlorogenic acid from Eucommia ulmodies leaves.
Publication date: 2015
Journal: Journal of Pharmaceutical and Biomedical Analysis
Volume: 114
Page numbers: 139-144.
DOI: 10.1016/j.jpba.2015.04.038
Alternative URL: http://www.sciencedirect.com/science/article/pii/S073170851500271X

Abstract: Molecularly imprinted polymers (MIPs) for chlorogenic acid (CGA) were prepared by modified precipitation polymerization using methacrylic acid as a functional monomer, divinylbenzene as a crosslinker and methanol or dimethylsulfoxide as a co-solvent. The prepared MIPs were microspheres with a narrow particle size distribution. Binding experiments and Scatchard analyses revealed that two classes of binding sites, high and low affinity sites, were formed on the MIP. The retention and molecular-recognition properties of the prepared MIP were evaluated using a mixture of water and acetonitrile as a mobile phase in hydrophilic interaction chromatography. With an increase of acetonitrile content, the retention factor of CGA was increased on the MIP. In addition to shape recognition, hydrophilic interactions seem to work for the recognition of CGA on the MIP. The MIP had a specific molecular-recognition ability for CGA, while other related compounds, such as caffeic acid, gallic acid, protocatechuic acid and vanillic acid, could not be recognized by the MIP. Furthermore, the MIP for CGA was successfully applied for extraction of CGA in the leaves of Eucommia ulmodies
Template and target information: chlorogenic acid, CGA
Author keywords: molecularly imprinted polymer, Modified precipitation polymerization, sample preparation, chlorogenic acid


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