MIPs logo MIPdatabase     MIP2018 Conference website
Custom Search
Reference type: Journal
Authors: Eslami MR, Alizadeh N
Article Title: A dual usage smart sorbent/recognition element based on nanostructured conducting molecularly imprinted polypyrrole for simultaneous potential-induced nanoextraction/determination of ibuprofen in biomedical samples by quartz crystal microbalance sensor.
Publication date: 2015
Journal: Sensors and Actuators B: Chemical
Volume: 220
Page numbers: 880-887.
DOI: 10.1016/j.snb.2015.06.017
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0925400515007893

Abstract: A selective detection strategy presented for ibuprofen (IBP) as a model anionic drug based on potential-induced uptake/release of the drug by a smart conducting molecularly imprinted polymer (CMIP) as sorbent/recognition element for simultaneous nanoextraction and determination of IBP in plasma samples by quartz crystal microbalance (QCM) without any additional treatment. The nanostructured CMIP film was directly synthesized by cyclic voltammetry method on the QCM gold electrode and applied for selective uptake of IBP from sample solution by the aid of positive potential and its successive release by negative potential. The frequency shifts of QCM in uptake and release steps were monitored and used as sensor signal for IBP sorption/determination. In the biomedical samples, the frequency shift of release step exhibited more linear and interference free behavior. Several parameters like synthesis conditions, potential, time, pH of uptake and release and exchange anion type were explored to achieve the optimal sorption/determination conditions. The calibration graph was linear in the ranges of 1-10 and 10-100 μmol L-1, the limit of detection was 0.05 μmol L-1 and RSD% (n = 5) was lower than 3%. The proposed method was successfully applied for quantification of trace amounts of IBP in biomedical samples and validated by HPLC method. The CMIP/QCM sensor shows a good long-term stability and the sensor response drops 10% after 80 cycles of measurement in 8th week
Template and target information: ibuprofen, IBP
Author keywords: quartz crystal microbalance, polypyrrole, Conducting molecularly imprinted polymer, Potential-induced uptake, release, ibuprofen, plasma


  Mister Benzene Get Well Soon card  Chemistry peptide mug  Beach bunny periodic table shirt

Molecules Special Issue call     Sensors Special Issue call






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon