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Reference type: Book Chapter
Authors: Wan YC, Ma HT, Lu B
Publication date: 2015
Chapter title: MIPs in Aqueous Environments.
Chapter number: 6
Page numbers: 131-166.
DOI: 10.1007/10_2015_317 Alternative URL: http://www.springer.com/978-3-319-20728-5

Book title: Molecularly Imprinted Polymers in Biotechnology
Editors: Mattiasson B, Ye L
Publisher: Springer
City: Berlin,Heidelberg
ISBN: 978-3-319-20728-5
Series title: Advances in Biochemical Engineering/Biotechnology

Abstract: When organic solvent-compatible molecularly imprinted polymers (MIPs) are used in aqueous environment, how to reduce nonspecific binding is a major challenge. By modifying the binding solvents and introducing appropriate washing and elution steps, even relatively hydrophobic MIPs can gain optimal rebinding selectivity in aqueous conditions. Furthermore, water-compatible MIPs that can be used to treat aqueous samples directly have been prepared. The use of hydrophilic co-monomers, the controlled surface modification through controlled radical polymerization, and the new interfacial molecular imprinting methods are different strategies to prepare water-compatible MIPs. By combining MIPs with other techniques, both organic solvent-compatible and water-compatible MIPs can display better functional performances in aqueous conditions. Intensive studies on MIPs in aqueous conditions can provide new MIPs with much-improved compatibilities that will lead to more interesting applications in biomedicine and biotechnology
Template and target information: Review - MIPs in aqueous environments
Author keywords: Aqueous conditions, Molecularly imprinted polymers, Preparation and application, Water-compatible, Organic solvent-compatible


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