Paper 1379

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Reference type: Journal
Authors: Yan M, Kapua A
Article Title: Fabrication of molecularly imprinted polymer microstructures.
Publication date: 2001
Journal: Analytica Chimica Acta
Volume: 435
Issue: (1)
Page numbers: 163-167.
DOI: 10.1016/S0003-2670(00)01355-6

Abstract: We report the combination of soft lithography and molecular imprinting for the fabrication of molecularly imprinted polymer (MIP) microstructures on silicon wafers. Proof-of-concept experiments were carried out using 2,4-dichlorophenoxyacetic (2,4-D) acid as the template molecule. The MIP microstructures were fabricated by employing micromolding in capillaries (MIMIC) and a soft poly(dimethylsiloxane) (PDMS) stamp containing 20 mum feature size relief structures. MIP micromonoliths with a cross-sectional dimension of 20 mum x 20 mum were isolated and used directly after extraction of the template. The binding characteristics of these imprinted polymer micromonoliths were studied using radioligand binding analysis. (C) 2001 Elsevier Science B.V. All rights reserved

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