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Reference type: Journal
Authors: Fernandez-Sanchez JF, Segura Carretero A, Cruces-Blanco C, Fernandez-Gutierrez A
Article Title: A sensitive fluorescence optosensor for analysing propranolol in pharmaceutical preparations and a test for its control in urine in sport.
Publication date: 2003
Journal: Journal of Pharmaceutical and Biomedical Analysis
Volume: 31
Issue: (5)
Page numbers: 859-865.
DOI: 10.1016/S0731-7085(02)00692-1

Abstract: We describe a simple and selective method for analysing propranolol and a sensitive test for its control in urine. A flow-through fluorescence optosensor based on on-line immobilization in a non-ionic-exchanger (Amberlite XAD-7) solid support in a continuous flow was used in both cases. Determination was made in 5 mM H2PO4 /HPO4 2 buffer solution at pH 6 at a working temperature of 20 8C. Fluorescence intensities were measured at lex/em/300/338 nm with a response time of 80 s, thus obtaining a linear concentration range of between 0 and 250.0 ng ml1 with a detection limit of 1.3 ng ml-1, an analytical sensitivity of 6.0 ng ml-1 and a standard deviation of 2.40% at a 150 ng ml-1 concentration level for propranolol. We also propose a test to detect propranolol in urine with a linear concentration range between 0 and 100.0 ng ml-1, a detection limit of 0.2 ng ml-1, an analytical sensitivity of 1.0 ng ml-1, and a standard deviation of 0.84% at a 75 ng ml-1 concentration level. The effect of proteins presents in urine samples were evaluated. The two proposed methods were satisfactorily applied to commercial formulations and urine samples respectively. 2003 Elsevier Science B.V. All rights reserved.

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