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Reference type: Journal
Authors: Chen CT, Chen YC
Article Title: Molecularly imprinted TiO2-matrix-assisted laser desorption/ionization mass spectrometry for selectively detecting a-cyclodextrin.
Publication date: 2004
Journal: Analytical Chemistry
Volume: 76
Issue: (5)
Page numbers: 1453-1457.
DOI: 10.1021/ac034986h

Abstract: This study describes a new means to conduct molecular recognition-based analysis using mass spectrometry. Taking advantage of the unique characteristic of the absorption capacity of the TiO2 sol-gel material in the UV region, a TiO2 sol-gel-deposited thin film was employed as the sample substrate to assist in UV laser desorption/ionization of analytes. Sol-gels are polymeric materials that are easy to prepare and modify at low temperatures. Molecularly imprinted TiO2 sol-gels were generated for molecular recognition-based analysis. alpha-Cyclodextrin (CD) was selected as the template molecule and doped into TiO2 in a sol-gel reaction. The molecularly imprinted TiO2 Sol was spin-coated on a glass slide, and appropriate template cavities in the TiO2 sol-gel material were formed after the template molecules were removed. We demonstrate that this modified glass slide can be used to select alpha-CD from a sample solution containing equal amounts of alpha-, beta-, and gamma-CD (50 ppb each, 18 mL); alpha-CD was directly detected from the modified glass slide by matrix- assisted laser desorption/ionization mass spectrometry without the addition of extra matrix. This approach provides a new detection method for molecular recognition-based analysis


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