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Reference type: Journal
Authors: Rosengren JP, Karlsson JG, Nicholls IA
Article Title: Enantioselective synthetic thalidomide receptors based upon DNA binding motifs.
Publication date: 2004
Journal: Organic & Biomolecular Chemistry
Volume: 2
Issue: (22)
Page numbers: 3374-3378.
DOI: 10.1039/b407996e

Abstract: A series of molecularly imprinted polymer (MIP) synthetic receptors selective for the sedative thalidomide ( 5) have been designed and synthesized based upon the functional monomer 9- (2'-methacryloyloxyethyl)adenine (2). H-1-NMR studies were used to establish the existence of DNA-like binding interactions between 2 and the template ( 5). A series of ethylene glycol dimethacrylate cross-linked copolymers was synthesized using either 2 or methacrylic acid, or a combination of these functional monomers. Zonal HPLC studies demonstrated enantioselectivity (a = 2.11) and ligand selectivity which could be attributed to the interaction of 2 with the imide moiety of 5. Compound 2 provided a more significant contribution to the binding of 5 than methacrylic acid, though a combination of these two functional monomers resulted in improved enantioselectivity. Frontal chromatographic and batch binding studies confirmed the observed differences in affinity of the imprinted and reference polymers for the template


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