MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Björk P, Persson NK, Peter K, Nilsson R, Åsberg P, Inganäs O
Article Title: Dynamics of complex formation between biological and luminescent conjugated polyelectrolytes - A surface plasmon resonance study.
Publication date: 2005
Journal: Biosensors and Bioelectronics
Volume: 20
Issue: (9)
Page numbers: 1764-1771.
DOI: 10.1016/j.bios.2004.07.001
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-4D34M4N-1/2/f2025eb1ea12556053e6b3efd540bc43

Abstract: A water-soluble polythiophene, POWT, with zwitterionic peptide like side chains possess good characteristics for biosensor applications. The zwitterionic side chains of the polymer can couple to biomolecules via electrostatic and hydrogen bonding. This creates possibilities to imprint biomolecules to spin-coated polymer films with maintained functionality, and use the resulting matrix as a biosensor. Polymer-biomolecular interaction studies done with surface plasmon resonance (SPR) reveal a well performing sensor matrix with high affinity for DNA hybridizations as well as for protein detection. The responses are distinct and very specific. A directional dependence of antibodies binding to POWT layer has also been observed. The polymer films have also been characterized by optical methods. Emission and absorption measurements in different buffer systems confirm that the polymer matrix can undergo structural and conformational changes on surfaces. The dielectric function in the interval 300-800 nm of POWT is reported, based on variable angle spectroscopic ellipsometry. This modeling reveals that a considerable amount of water is included in the material. The polymer layer possesses the characteristics needed for biochip applications and micro array techniques
Template and target information: oligonucletides, DNA, proteins, antibodies
Author keywords: DNA, protein, SPR, sensor, conjugated polymer, ellipsometry

  Mister Benzene Leaving card  Chemistry peptide mug  Beach bunny periodic table shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner