MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Xu YL, Liu ZS, Wang HF, Yan C, Gao RY
Article Title: Chiral recognition ability of an (S)-naproxen-imprinted monolith by capillary electrochromatography.
Publication date: 2005
Journal: Electrophoresis
Volume: 26
Issue: (4-5)
Page numbers: 804-811.
DOI: 10.1002/elps.200410171

Abstract: The racemic naproxen was selectively recognized by capillary electrochromatography (CEC) on an (S)-naproxen-imprinted monolith, which was prepared by an in situ thermal-initiated polymerization. The recognition selectivity of a selected monolith strictly relied on the CEC conditions involved. The factors that influence the imprinting selectivity as well as the electroosmotic flow (EOF), including the applied voltage, organic solvent, salt concentration and pH value of the buffer, column temperature, and surfactant modifiers were systematically studied. Once the column was prepared, the experiment results showed that the successful chiral recognition was dependent on CEC variables. For example: the recognition could be observed in acetonitrile and ethanol electrolytes, while methanol and dimethyl sulfoxide (DMSO) electrolytes had no chiral recognition ability. The buffer with pH values of 2.6 or 3.0 at a higher salt concentration had chiral recognition ability. Column temperatures of 25- 35degreesC were optimal. Three surfactants, sodium dodecyl sulfate (SDS), cetyltrimethylammoniurn bromide (CTAB), and polyoxyethylene sorbitan monolaurate (Tween 20), can improve the recognition. Baseline resolution was obtained under optimized conditions and the column efficiency of the later eluent (S)-naproxen was 90 000 plates/m
Template and target information: (S)-naproxen
Author keywords: capillary electrochromatography, chiral recognition, molecular imprinted monolith, naproxen

  Mister Benzene and Mister Cyloheptatetraene shirt  Chemistry peptide mug  Beach bunny periodic table shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner