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Reference type: Journal
Authors: Yeh WM, Ho KC
Article Title: Amperometric morphine sensing using a molecularly imprinted polymer-modified electrode.
Publication date: 2005
Journal: Analytica Chimica Acta
Volume: 542
Issue: (1)
Page numbers: 76-82.
DOI: 10.1016/j.aca.2005.01.071
Alternative URL: http://ntur.lib.ntu.edu.tw/bitstream/246246/87284/1/21.pdf

Abstract: This study incorporates morphine into a molecularly imprinted polymer (MIP) for the amperometric detection of morphine. The polymer, poly(3,4-ethylenedioxythiophene), PEDOT, is an electroactive film that catalyzes morphine oxidation and lowers the oxidization potential on an indium tin oxide (ITO) electrode. The MIP-PEDOT modified electrode is prepared by electropolymerizing PEDOT onto an ITO electrode in a 0.1 M LiClO4 solution with template addition (morphine). After template molecule extraction, the oxidizing current of the MIP-PEDOT modified electrode is measured in a 0.1 M KCl solution (pH = 5.3) at 0.75 V (versus Ag/AgCl/sat'd KCl) with the morphine concentration varying in the 0.1-5 mM range. A linear range, displaying the relationship between steady-state currents and morphine concentrations, from 0.1 to 1 mM, is obtained. The proposed amperometric sensor could be used for morphine detection with a sensitivity of 91.86 μA/cm2 per mM. A detection limit of 0.2 mM at a signal-to-noise ratio of 3 is achieved. Moreover, the proposed method can discriminate between morphine and its analogs, such as codeine
Template and target information: morphine
Author keywords: amperometric detection, molecularly imprinted polymer (MIP), morphine, PEDOT


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