MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Dirion B, Lanza F, Sellergren B, Chassaing C, Venn R, Berggren C
Article Title: Selective solid phase extraction of a drug lead compound using molecularly imprinted polymers prepared by the target analogue approach.
Publication date: 2002
Journal: Chromatographia
Volume: 56
Issue: (3-4)
Page numbers: 237-241.
DOI: 10.1007/BF02493219

Abstract: Molecularly imprinted polymers have been evaluated at the sample clean-up stage in the analysis of a drug lead compound. In order to circumvent quantification problems related to bleeding of the template, a structurally related analogue of the latter was used. This was selected based on criteria related to interaction site location, solubility, availability and stability of the analogue. Selection of suitable polymerisation conditions was then made using a small batch format (ca. 50 mg) and rapid assessment of binding in the equilibrium mode. It was found that the amount of template could be greatly reduced compared to the conventional protocol, requiring only 5 mumol of template per gram of polymer without seriously compromising the performance of the materials for chromatographic or SPE applications

  Bag featuring the name Francesca spelled out in symbols of the chemical elements  Periodic table Bag bag  Meerkat somebody mention coffee mug

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner