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Reference type: Journal
Authors: Liu ZS, Xu YL, Yan C, Gao RY
Article Title: Mechanism of molecular recognition on molecular imprinted monolith by capillary electrochromatography.
Publication date: 2005
Journal: Journal of Chromatography A
Volume: 1087
Issue: (1-2)
Page numbers: 20-28.
DOI: 10.1016/j.chroma.2005.05.107
Alternative URL: http://www.sciencedirect.com/science/article/B6TG8-4GKWJ1H-1/2/a6be3003655ca0c1c35f169dd44d7e54

Abstract: The recognition mechanism of molecularly imprinted polymer (MIP) in capillary electrochromatography (CEC) is complicated since it possesses a hybrid process, which comprises the features of chromatographic retention, electrophoretic migration and molecular imprinting. For an understanding of the molecular recognition of MIP in CEC, a monolithic MIP in a capillary with 1,1'-binaphthyl-2,2'-diamine (BNA) imprinting was prepared by in situ copolymerization of imprinted molecule, methacrylic acid and ethylene glycol dimethacrylate in porogenic solvent, a mixture of toluene-isooctane. Strong recognition ability and high column performance (theory plates was 43,000 plates/m) of BNA were achieved on this monolithic MIP in CEC mode. In addition, BNA and its structural analogue, 1,1'-bi-2, 2'-naphthol, differing in functional groups, were used as model compounds to study imprinting effect on the resultant BNA-imprinted monolithic column, a reference column without imprinting of BNA and a open capillary. The effects of organic modifier concentration, pH value of buffer, salt concentration of buffer and column temperature on the retention and recognition of two compounds were investigated. The results showed that the molecular recognition on MIP monolith in CEC mode mainly derived from imprinting cavities on BNA-imprinted polymer other than chromatographic retention and electrophoretic migration
Template and target information: 1,1'-binaphthyl-2,2'-diamine, BNA
Author keywords: molecularly imprinted polymer, monolith, capillary electrochromatography, 1,1'-Binaphthyl-2,2'-diamine, recognition mechanism


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