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Authors: Hishiya T, Akiyama T, Asawa T, Asanuma H, Komiyama M
Publication date: 2002
Article title: Imprinted cyclodextrin polymers on silica surface for the preparation of HPLC stationary phases.
Page numbers: 330
Alternative URL: http://www.jstage.jst.go.jp/article/spsjppj/51/0/51_330/_article
Proceedings title: Polymer Preprints, Japan
Volume number: 51
Abstract: We have recently reported that molecularly imprinted cyclodextrin (CyD) polymers recognize nano-scale guests in water. In the present study, acryloyl-b-cyclodextrin was molecularly imprinted on silica particles in the presence of templates for the preparation of HPLC stationary phases. Host monomer of 2-O-acryloyl-b-CyD (sec-CyD) or acryloyl-6-amino-6-deoxy-b-CyD (pri-CyD) was cross-linked with methylenebisacrylamide in water. The resultant imprinted polymers retained the targets (templates) more strongly than those prepared in the absence of the templates. Selective promotion of retention time by imprinting was larger when pri-CyD was used as a host. By using sec-CyD as a host, control of enantio-selectivity toward the template was also successful. Conclusively, immobilized imprinted CyD polymers on silica particles are useful stationary phases of nano-scale guests in water.
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