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Reference type: Journal
Authors: Miyata T, Hayashi T, Uragami T
Article Title: Relationship between cross-linked structure and humor-marker-responsive behavior of glycoprotein-imprinted gels.
Publication date: 2005
Journal: Polymer Preprints, Japan
Volume: 54
Issue: (1)
Page numbers: 1790.

Abstract: Stimuli-responsive gels undergo their volume changes in response to external stimuli such as pH and temperature. In this study, novel stimuli-responsive gels which can respond to a specific glycoprotein (?-fetprotein:AFP) were prepared by molecular imprinting using lectin and antibody as ligands for AFP ard high-molecular-weight cross-linkers. The resultant AFP-imprinted gels shrank in the presence of AFP due to the formation of lectin-AFP-antibody complexes, but swelled slightly in the presence of ovalbumin. The AFP-imprinted gels with high-molecular-weight cross-linkers shrank more strongly than that with a low-molecular-weight cross-linker. Using high-molecular-weight cross-linkers in preparing glycoprotein-imprinted gels resulted in improving their glycoprotein-responsive behavior
Author keywords: antibody, glycoprotein, lectin, ligand, molecular imprinting, stimuli-responsive gel, Tumor marker


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