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Reference type: Journal
Authors: Haginaka J, Sanbe H
Article Title: Uniform-sized molecularly imprinted polymers for 2-arylpropionic acid derivatives selectively modified with hydrophilic external layer and their applications to direct serum injection analysis.
Publication date: 2000
Journal: Analytical Chemistry
Volume: 72
Issue: (21)
Page numbers: 5206-5210.
DOI: 10.1021/ac0005215
Alternative URL: http://lib3.dss.go.th/fulltext/Journal/Analytical%20Chemistry/2000/v72no21p5143-5519/2000v72no.21p.5206-5210.pdf

Abstract: Uniform-sized molecularly imprinted polymers (MIPs) for (S)- naproxen and -ibuprofen selectively modified with hydrophilic external layer, restricted access media (RAM)-MIPs,have been prepared. First, the MIP for (S)naproxen or -ibuprofen was prepared using 4-vinylpyridine and ethylene glycol dimethacrylate as a functional monomer and cross-linker, respectively, by a multistep swelling and thermal polymerization method. Next, a 1:1 mixture of glycerol monomethacrylate and glycerol dimethacrylate was used for hydrophilic surface modification, and it was added directly to the MIP for (S)-naproxen or -ibuprofen 4 h after the start of molecular imprinting. The obtained RAM-MIP material for (S)- naproxen or -ibuprofen was applied for direct serum injection assays of the drug by a column-switching system, consisting of a RAM-MIP material and conventional C18-silica column, However, leakage of the imprint molecule prevented accurate and precise assays of the drug. This problem has been overcome by using the RAM-MIP for (S)-naproxen for the assays of ibuprofen in rat plasma. The optimized column-switching system was applied successfully to the assay of ibuprofen in rat plasma after oral administration
Template and target information: S-naproxen, S-ibuprofen

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