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Reference type: Journal
Authors: Weng CH, Yeh WM, Ho KC, Lee GB
Article Title: A microfluidic system utilizing molecularly imprinted polymer films for amperometric detection of morphine.
Publication date: 2007
Journal: Sensors and Actuators B: Chemical
Volume: 121
Issue: (2)
Page numbers: 576-582.
DOI: 10.1016/j.snb.2006.04.111
Alternative URL: http://www.sciencedirect.com/science/article/B6THH-4K5HWD8-2/2/78abb5bcb3a8f90fc1b6ef8026428cca

Abstract: This study reports a microfluidic system for detecting morphine (MO) using a combination of a molecularly imprinted polymer (MIP) and electrochemical sensing techniques. A monomer, called 3,4-ethylenedioxythiophene (EDOT), was used to mix with morphine molecules through an electropolymerization process on a sensing electrode. The modified MIP-PEDOT (poly-ethylenedioxythiophene as the imprinting polymer with MO as the template) electrode was then used for detecting the morphine via the amperometric method. Key components including MIP films, a PDMS (polydimethylsiloxane)-based microchannel, a peristaltic micropump, microvalves and sensing microelectrodes were integrated to form a new microfluidic system for morphine sensing utilizing MEMS (micro-electro-mechanical-systems) technologies. The morphine samples were automatically transported to the MIP-PEDOT sensing electrode using the peristaltic micropump. Then, the morphine was detected using the electrochemical method. Experimental data show that the sensitivity of the MIP-PEDOT morphine sensor is 171.5 μA/cm2 mM in detecting morphine concentration ranging from 0.01 to 0.2 mM at a flow rate of 92.3 μl/min. The novel combination of microfluidics, MIP, and electrochemical sensing technologies provides a promising approach for highly sensitive, highly selective morphine sensing with a low sample consumption rate. More importantly, the whole process can be performed in an automatic format by using the enabling microfluidic technology. A multi-functional electrochemical detection system is feasible using similar microfluidics/MIP/electrochemical technologies
Template and target information: morphine, MO
Author keywords: molecularly imprinted polymer, Microfluidics, Micropumps, MEMS, morphine, Electrochemical, amperometric detection


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