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Reference type: Journal
Authors: Zhu QJ, Tang J, Dai J, Gu XH, Chen SW
Article Title: Synthesis and characteristics of imprinted 17-β-estradiol microparticle and nanoparticle with TFMAA as functional monomer.
Publication date: 2007
Journal: Journal of Applied Polymer Science
Volume: 104
Issue: (3)
Page numbers: 1551-1558.
DOI: 10.1002/app.25564
Alternative URL: http://www.spm.com.cn/papers/534.pdf

Abstract: Submicron-scaled molecularly imprinted polymer (MIP) particles for 17-β-estradiol were prepared by precipitation polymerization method using 2-(trifluoromethyl) acrylic acid as functional monomer and trimethylolpropane trimethacrylate as cross-linker in acetonitrile. The obtained submicron-scaled MIP particles were subsequently packed into stainless steel columns and the chromatographic characteristics of the MIP stationary phase were investigated. Interestingly, it was found that tandem MIP columns of 17-β-estradiol-based MIP with two different ratios of the template could achieve almost complete separation of isomers (17-α-estradiol and 17-β-estradiol) with a good separation factor (2.45). Morphological characteristics and adsorption kinetics of the submicron-scaled MIP particles, effect of flow-rate, injection amount, and column temperature on separation were also investigated in detail. Results indicated that the submicron-scaled MIP particles had both good selectivity and high affinity to the template molecule 17-β-estradiol. 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 1551-1558, 2007
Template and target information: 17-β-estradiol
Author keywords: β-estradiol, Molecularly imprinted polymers, precipitation polymerization, molecular recognition, hormone, food safety

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