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Reference type: Journal
Authors: Peppas NA, Byrne ME
Article Title: New biomaterials for intelligent biosensing, recognitive drug delivery and therapeutics.
Publication date: 2003
Journal: B. T. Gattefossé
Issue: (96)
Page numbers: 25-37.
Alternative URL: http://www.che.utexas.edu/research/biomat/PDFReprints/JGaleni_96_25-37(2003).pdf

Abstract: Engineering the molecular design of intelligent biomaterials by controlling recognition and specificity is the first step in coordinating and duplicating complex biological and physiological processes. We address design and synthesis characteristics of artificial molecular structures capable of specific molecular recognition of biological molecules. Recent developments in protein delivery have been directed towards the preparation of targeted formulations for protein delivery to specific sites, use of environmentally-responsive polymers to achieve pH- or temperature-triggered delivery, usually in modulated mode, and improvement of the behavior of their mucoadhesive behavior and cell recognition. Molecular imprinting and microimprinting techniques, which create stereo-specific threedimensional binding cavities based on a biological compound of interest can lead to preparation of biomimetic materials for intelligent drug delivery, drug targeting, and tissue engineering. We have been successful in synthesizing novel glucose-binding molecules based on non-covalent directed interactions formed via molecular imprinting techniques within aqueous media.


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