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Abstract: Novel biodegradable molecularly imprinted polymers (MIP) based on poly(3-hydroxybutyrate) (PHB) were prepared and characterized. Low molecular weight PHB diol was prepared from bacterial PHB, and was used to synthesize acrylate end-capped PHB macromer. The synthesis of hydroxyl-telechelic PHB and acrylate end-capped macromer was confirmed using FT-IR and 1H NMR. PHB macromer was used to prepare biodegradable crosslinked networks by photopolymerization with functional monomer (methacrylic acid) and a model template (theophylline). The theophylline-imprinted polymer showed higher binding capacity for theophylline than non-imprinted polymer (NIP). The data of theopylline binding into the theopylline-imprinted polymer correlated well with the Scatchard plot. The equilibrium binding constant (KE) and the total number of bound sites of MIP ([PS]total) were 7.1 × 103 M-1 and 18.5 μmol/g, respectively, which were estimated from the negative slope and intercept in the Scatchard plot
Template and target information: theophylline
Author keywords: biodegradable, Biomaterials, molecular recognition, molecularly imprinted polymer, poly(3-hydroxybutyrate)