MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Mohamed R, Richoz-Payot J, Gremaud E, Mottier P, Yilmaz E, Tabet JC, Guy PA
Article Title: Advantages of Molecularly Imprinted Polymers LC-ESI-MS/MS for the Selective Extraction and Quantification of Chloramphenicol in Milk-Based Matrixes. Comparison with a Classical Sample Preparation.
Publication date: 2007
Journal: Analytical Chemistry
Volume: 79
Issue: (24)
Page numbers: 9557-9565.
DOI: 10.1021/ac7019859

Abstract: Abstract: A simple and fast selective extraction of the antibiotic chloramphenicol (CAP) from milk (raw milk, skimmed milk, and milk powder) using a molecularly imprinted polymer (MIP) sorbent is described. The method entails a single centrifugation step prior to loading the supernatant onto the MIP cartridge and subsequent elution with a mixture of solvents. CAP was further analyzed by isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) operating in negative ionization acquisition mode. The advantages of the MIP approach were assessed by comparing the data generated from a classical solid-phase and liquid-liquid extractions procedure, previously developed in our laboratory. A better recovery of CAP due to an enhanced selectivity and a faster turnaround time (18 samples processed within 3 h compared to 8 h with the classical approach) were evidenced when using the MIP cleanup. The analysis of CAP in raw milk was further validated according to the 2002/657/EC European Union criteria for the analysis of veterinary drug residues at the minimum required performance limit (MRPL) of 0.3 g/kg, using CAP-d5 as internal standard. Non-internal-standard corrected recovery values ranged between 50% and 87% over the range of concentrations considered. The decision limit (CC) and detection capability (CC) were calculated to be 0.06 and 0.10 g/kg, respectively
Template and target information: chloramphenicol, CAP

  SMI logo lapel pin  Periodic table Smart hat  Lab Chick script shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner