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Reference type: Journal
Authors: Thoelen R, Vansweevelt R, Duchateau J, Horemans F, D'Haen J, Lutsen L, Vanderzande D, Ameloot M, vandeVen M, Cleij TJ, Wagner P
Article Title: A MIP-based impedimetric sensor for the detection of low-MW molecules.
Publication date: 2008
Journal: Biosensors and Bioelectronics
Volume: 23
Issue: (6)
Page numbers: 913-918.
DOI: 10.1016/j.bios.2007.08.020
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-4PKPGPV-5/2/c87762cc26b6f233ef4d53ebd8ce2cc0

Abstract: Mimicking the selectivity and sensitivity of biological systems for sensor devices is of increasing interest in biomedical, environmental and chemical analysis. Synthetic materials with imprinted nanocavities, acting as highly selective artificial receptors, are a tailor-made solution in obtaining such a sensor. Incorporation of such molecularly imprinted polymers (MIPs) in a platform suitable for electrochemical measurements, can offer high sensitivity together with device miniaturization and an electronic read-out. As a proof of principle, a MIP-based sensor for l-nicotine has been developed. To this end, the molecular structure of l-nicotine was imprinted in a polymer matrix of polymethacrylic acid (PMAA). Subsequently, microparticles of the imprinted polymer were immobilized on thin films of the conjugated polymer OC1C10-PPV. These films were incorporated in an impedimetric sensing device. Using electrochemical impedance spectroscopy, the real part of the impedance was monitored for various concentrations. This setup allows for the detection of l-nicotine from 1 to 10 nM and is insensitive for the resembling molecule l-cotinine
Author keywords: molecular imprinting, l-Nicotine sensor, impedance spectroscopy, conjugated polymers

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