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Reference type: Journal
Authors: Hung CY, Huang YT, Huang HH, Hwang CC
Article Title: Sulfamethazine and sulfadimethoxine separation strategies based on molecularly imprinted adsorbents.
Publication date: 2007
Journal: Analytical Letters
Volume: 40
Issue: (17)
Page numbers: 3232-3244.
DOI: 10.1080/00032710701672707
Alternative URL: http://www.informaworld.com/10.1080/00032710701672707

Abstract: The synthesis of molecularly imprinted polymer (MIP) as a stationary phase of high-performance liquid chromatography (HPLC), for the efficient determination of sulfamethazine and sulfadimethoxine in tablets is reported. The polymers were prepared by a noncovalent method with sulfamethazine as the template, methacrylic acid as the functional monomer and ethylene glycoldimethacrylate as the cross-linker in the presence of chloroform as the solvent. The retention time of sulfamethazine and sulfadimethoxine were approximately 5.2 +/- 0.2 and 10.3 +/- 0.5 min, respectively. In order to compare the chromatographic data from the stationary phase, retention factor (k) and separation factors (alpha) were given. The values of alpha were 2.05 similar to 2.17 showed that the MIP was able to recognize structurally subtle differences from the template molecule. The MIP was successfully applied to commercial tablet analysis and the result showed a good recovery with 99 and 98% for sulfamethazine and sulfadimethoxine
Template and target information: sulfamethazine, sulfadimethoxine
Author keywords: molecularly imprinted polymer, high-performance liquid chromatography, sulfamethazine, sulfadimethoxine

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