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Reference type: Book Chapter
Authors: Wang XD, Li WY, Rasmussen H
Publication date: 2007
Chapter title: Chiral separations.
Chapter number: 5
Page numbers: 111-144.
DOI: 10.1016/S0149-6395(07)80011-0 Alternative URL: http://www.sciencedirect.com/science/article/B8GXS-4PNDTDG-7/2/1645ca4d1033e7f2d233361f2c7e97ee

Book title: Separation Science and Technology: HPLC Method Development for Pharmaceuticals
Editors: Ahuja S, Rasmussen H
Publisher: Academic Press
Volume number: 8

Abstract: This chapter discusses chiral separation of active pharmaceutical ingredients (APIs) and their related compounds by various methods. Particular emphases have been put on chiral separation by HPLC on chiral stationary phases (CSPs). Different types of CSPs, including polysaccharide derivatives, macrocyclic glycopeptides (antibiotics), cyclodextrins, Pirkletype, proteins, ligand exchange, crown ethers, synthetic polymers/molecularly imprinted polymers (MIPs), are discussed. Separation mechanisms and method development for chiral molecules using these phases are also discussed
Template and target information: Review - chiral separations

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