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Reference type: Journal
Authors: Dickert FL, Jenik M, Lieberzeit PA, Grillberger P, Schirhagl R, Seifner A, Paul G
Article Title: QCM-sensorik von Biopartikein: Von Nano zu Mikro - Von Bio zu Kunststoff - Von Sauerbrey zu Nichtsauerbrey.
Publication date: 2008
Journal: VDI Berichte
Volume: 2011
Page numbers: 43-52.

Abstract: Mass-sensitive sensors for bioanalytes, e. g. viruses, cells and pollen, have been developed on the basis of molecular imprinting techniques. For this purpose polymer surfaces are structured with stamping procedures thus leading to negatives of the template on these layers. The combination of the generated MIP-layers with quartz crystal microbalances (QCM) allows a sensor-based detection of these bioparticles having various dimensions without using time-consuming pre-treatment procedures. Apart from selective detection of different picornaviruses, like the human rhinovirus (HRV) and the food-and-mouth-disease virus (FMDV), a distinction between serotypes of the viruses was achieved with the generated sensors. In the case of yeast, the detection of the cell's stage of development is enabled with the manufactured sensors. During these investigations we observed unusual effects leading to an increase of the resonance frequency of the device and hence showing Non-Sauerbrey-behaviour. Sensors for larger analytes like pollen (25?m) showed a similar response behaviour allowing further investigations of these effects


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