Abstract: In view of technological significance of molecular imprinting polymers in drug delivery, the present study is an attempt to synthesize 2-hydroxyethylmetacrylate (HEMA) and acrylic acid (AAc) based hydrogels imprinted with model drug glucose. Both molecular imprinted polymers (MIPs) and non-imprinted polymers (NIPs) have been synthesized and have been used to study their binding affinity, swelling and in vitro release dynamics of the drug. It has been observed from this study that the template formed in MIPs has increased the absorption percentage of the drug and has improved the release profile of the drug from these polymers.
Template and target information: glucose
Author keywords: drug delivery devices, hydrogels, molecular imprinted polymers, release dynamics, swelling kinetics