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Reference type: Journal
Authors: Li SJ, Huang X, Zheng MX, Li WK
Article Title: Molecularly imprinted polymers: modulating molecular recognition by a thermal phase transition in the binding framework.
Publication date: 2008
Journal: Analytical and Bioanalytical Chemistry
Volume: 392
Issue: (1)
Page numbers: 177-185.
DOI: 10.1007/s00216-008-2254-y

Abstract: Abstract: The concept used to realize the modulation of molecular recognition in a molecularly imprinted polymer is presented. Creating a thermal phase transition within the binding framework, the imprinted material was prepared using Boc-phenylalanine as the template and pNIPAM as the sensitive unit. The results indicate that such a transition causes a clear modulation in the recognition behavior of the prepared polymer which depends on the operation temperature. At a relatively low temperature, the prepared polymer acts like a traditionally imprinted one, showing a highly specific recognition for the imprint species. However, the prepared polymer does not present any notable resolution at 40 ŚC. This recognition behavior is comparable to a process that can be switched on and off, thus making modulated recognition feasible
Template and target information: Boc-phenylalanine, Boc-Phe
Author keywords: molecular imprinting, polymers, molecular recognition, modulation

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