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Reference type: Journal
Authors: Giovannoli C, Baggiani C, Anfossi L, Giraudi G
Article Title: Aptamers and molecularly imprinted polymers as artificial biomimetic receptors in affinity capillary electrophoresis and electrochromatography.
Publication date: 2008
Journal: Electrophoresis
Volume: 29
Issue: (16)
Page numbers: 3349-3365.
DOI: 10.1002/elps.200800004

Abstract: Artificial biomimetic receptors, such as aptamers and molecular-imprinted polymers, show antibody-like properties which are due to molecular recognition phenomena characterized by high affinity and selectivity. These binding features have made them suitable in all those application fields in which selective recognition is required. Thus, it is not surprising that they are finding applications in affinity CE as well. Recently, a variety of ACE methods have shown themselves to be suitable tools to provide a detailed quantitative characterization of the thermodynamic and kinetic aspects of binding. At the same time, affinity CE can exploit the peculiarities of these binding interactions to set up CE-based analytical tools for the separation and the determination of specific target molecules in microscale formats. This review will provide a detailed description of affinity CE methods recently reported in the literature and related to these topics
Template and target information: Review - MIPs and aptamers in capillary electrophoresis and electrochromatography
Author keywords: affinity capillary electrophoresis, Aptamers, biomimetic receptors, molecular imprinting, molecular recognition


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