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Reference type: Journal
Authors: Rezaei B, Jafari MT, Khademi R
Article Title: Selective separation and determination of primidone in pharmaceutical and human serum samples using molecular imprinted polymer-electrospray ionization ion mobility spectrometry (MIP-ESI-IMS).
Publication date: 2009
Journal: Talanta
Volume: 79
Issue: (3)
Page numbers: 669-675.
DOI: 10.1016/j.talanta.2009.04.046
Alternative URL: http://www.sciencedirect.com/science/article/B6THP-4W6Y332-C/2/6ee2de84b900b4e3cb69b1b2adb40e21

Abstract: Application of electrospray ionization ion mobility spectrometry (ESI-IMS) as the detection technique for separation method based on molecular imprinted polymer (MIP) was investigated and evaluated. The method is exhaustively validated, including sensitivity, selectivity, recovery, reproducibility, and column capacity. The linear dynamic range of 0.02-2.00 μg mL-1 was obtained for primidone analysis with ESI-IMS. The recovery of drug analyzed was calculated to be above 90% and the relative standard deviation (RSD), was below 3% for all experiments. Various real samples were analyzed with the coupled techniques, and the results obtained revealed the efficient clean-up of the samples using MIP separation before the analysis by ESI-IMS as a detection technique
Template and target information: Primidone, 5-ethyl-5-phenyl-hexahydropyrimidine-4,6-dione
Author keywords: molecular imprinted polymer, Electrospray ionization, ion mobility spectrometry, Primidone

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