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Reference type: Journal
Authors: Zhou YM, Zhang CL, Lei JD, Ma TS, Ma GH, Su ZG, Chao Y
Article Title: Molecular imprinting-flow injection chemiluminescence method for determination of doxycycline hydrochloride.
Publication date: 2009
Journal: Spectroscopy and Spectral Analysis
Volume: 29
Issue: (7)
Page numbers: 1745-1749.
DOI: 10.3964/j.issn.1000-0593(2009)07-1745-05
Alternative URL: http://www.gpxygpfx.com/qikan/epaper/zhaiyao.asp?bsid=16465

Abstract: Doxycycline hydrochloride can enhance the chemiluminescence of potassium ferricyanide and luminol in alkaline medium. So a molecular imprinting-flow-injection chemiluminescence method for the determination of doxycycline hydrochloride was established by using doxycycline hydrochloride-imprinted polymers as recognition material and potassium ferricyanide and luminol as detection system. Doxycycline hydrochloride-imprinted polymer was synthesized using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as cross-linker. The linear range is 9.0 x 10-7 - 6.0 x 10-5 g mL-1 and the detection limit is 3.2 x 10-7 g mL-1. The relative standard deviation for 6.0 x 10-6 g mL-1 of doxycycline hydrochloride was 3.5% (n=9). This method has been successfully applied to the determination of doxycycline hydrochloride in tablets and in urine samples
Template and target information: doxycycline hydrochloride
Author keywords: chemiluminescence, Doxycycline hydrochloride, flow-injection, molecularly imprinted polymer

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