MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Kobayashi T, Fukaya T, Abe M, Fujii N
Article Title: Phase inversion molecular imprinting by using template copolymers for high substrate recognition.
Publication date: 2002
Journal: Langmuir
Volume: 18
Issue: (7)
Page numbers: 2866-2872.
DOI: 10.1021/la0106586

Abstract: Phase inversion molecular imprinting of theophylline (THO) was performed using acrylonitrile (AN) copolymers with acrylic acid (AA) (P(AN-co-AA)) and methacrylic acid (MA) (P(AN-co-MA). These copolymers were synthesized in the presence of the THO template at different template concentrations with [THO]/[COON] = 0.4, 1, and 2. Then, polymer solutions were casted and phase- inversed in water to prepare THO-imprinted copolymers. After template extraction, heterogeneous binding experiments of THO and its analogues caffeine, hydroxyethyl THO, uracil, theobromine, lumazine, and purine were performed. It was found that binding amounts of THO depended on [THO]/[COON]. At [THO]/[COON] = 1, THO-imprinted copolymers bound effectively to the THO substrate. Comparison was made by H-1 NMR experiments for a monomer solution with THO and copolymers prepared with and without template polymerization. Evidence showed that the template interacted with the COON proton in the monomer solution via hydrogen bonding and that template copolymerizations caused a conformation change of copolymer segments. Resultant template copolymers had selective recognition to THO, and effective imprinting of template copolymers with MA segments was observed

  Live and Let MIP spoof movie poster customisable greetings card  Chemistry peptide mug  Chemists are fun customisable shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner