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Reference type: Journal
Authors: Lee TT, Huang IB, Hwang CC
Article Title: Analysis of Sulfachloropyridazine and Sulfapyridine by High-Performance Liquid Chromatography with Molecularly Imprinted Polymer As the Stationary Phase.
Publication date: 2009
Journal: Biomedical Engineering-Applications Basis Communications
Volume: 21
Issue: (6)
Page numbers: 457-460.
DOI: 10.4015/S1016237209001647

Abstract: A simple and sensitive high performance liquid chromatographic method for simultaneous determination of sulfachloropyridazine and sulfapyridine has been developed. This method was developed by using self-prepared molecularly imprinted polymers (MIPs) as the stationary phase. The polymers were prepared by a noncovalent method with sulfachloropyridazine as the template, methacrylic acid as the functional monomer and ethylene glycoldimethacrylate as the cross-linker in the presence of chloroform as the solvent. In order to compare the chromatographic data from the stationary phase, the retention time of sulfachloropyridazine and sulfapyridine was given. The separation factors (alpha) were 1.79-1.89 that showed that the MIPs were able to recognize sulfachloropyridazine and sulfapyridine
Template and target information: sulfachloropyridazine, sulfapyridine
Author keywords: High performance liquid chromatographic, Sulfachloropyridazine, sulfapyridine, molecularly imprinted polymers (MIPs)


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