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Reference type: Journal
Authors: Yang ML, Gu WC, Sun L, Zhang F, Ling Y, Chu XG, Wang DN
Article Title: Study on the molecularly imprinted polymers with methyl-testosterone as the template.
Publication date: 2010
Journal: Talanta
Volume: 81
Issue: (1-2)
Page numbers: 156-161.
DOI: 10.1016/j.talanta.2009.11.051
Alternative URL: http://www.sciencedirect.com/science/article/B6THP-4XTG3B9-1/2/d2b9d85ea37beddb506c5bf90bce8aa7

Abstract: Molecularly imprinted polymers (MIPs) using methyl-testosterone as the template, methacrylic acid (MAA) as the monomer and ethylene glycol dimethacrylate (EDMA) as the crosslinker were prepared by precipitation polymerization. The morphology of the obtained particles was characterized by scanning electron microscopy (SEM) and the pore size was measured by BET. Then, the specificity and selectivity of the MIPs were evaluated using the equilibrium rebinding experiments. Besides, the MIPs were also used as the stationary phase of HPLC column and the retention behaviour to the template and analogues was confirmed using HPLC-MS-MS. Finally, the real application of the methyl-testosterone imprinted polymers was evaluated using SPE procedure with the spiked tap water and lake water. The results indicated that the prepared methyl-testosterone imprinted polymer showed specific rebinding ability to its template and could retain the template strongly compared with other structural analogues. At the same time, the MIPs could be used as SPE column to enrich methyl-testosterone in the lake water and show broad prospects in real samples
Template and target information: methyl-testosterone
Author keywords: Molecularly imprinted polymers, Methyl-testosterone, HPLC-MS-MS, Rebinding experiments, solid phase extraction


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