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Reference type: Journal
Authors: Ansell RJ, Mosbach K
Article Title: Magnetic molecularly imprinted polymer beads for drug radioligand binding assay.
Publication date: 1998
Journal: Analyst
Volume: 123
Issue: (7)
Page numbers: 1611-1616.
DOI: 10.1039/a801903g
Alternative URL: http://lib3.dss.go.th/fulltext/Journal/analyst/Analyst1998/no.7/1998v123n7p1611-1616.pdf

Abstract: Molecularly imprinted polymer-magnetic iron oxide composite materials which exhibit recognition properties and fan be withdrawn from solution by application of a magnetic field were prepared for the first time. Magnetic iron oxide was incorporated using a suspension polymerisation methodology with a perfluorocarbon liquid as the dispersing phase for the preparation of methacrylic acid-1,1,1- trimethylolpropane trimethacrylate copolymer beads molecularly imprinted with the beta-hlocker (S)-propranolol. The resulting superparamagnetic imprinted polymer beads were capable of binding [H- 3]-(S)-propranolol more strongly than a non-imprinted, otherwise identical, polymer. In a competitive radioligand binding assay using a magnet to separate polymer from solution, (R)-propranolol and (R,S)-metoprolol exhibited cross-reactivities of 19 and 0.7%, respectively, compared with (S)-propranolol
Template and target information: (S)-propranolol


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