MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Chang PP, Zhang ZJ, Yang CY
Article Title: Molecularly imprinted polymer-based chemiluminescence array sensor for the detection of proline.
Publication date: 2010
Journal: Analytica Chimica Acta
Volume: 666
Issue: (1-2)
Page numbers: 70-75.
DOI: 10.1016/j.aca.2010.03.031
Alternative URL: http://www.sciencedirect.com/science/article/B6TF4-4YNT497-3/2/38a9c87e745f158b22018c9be11b702d

Abstract: A new molecularly imprinted polymer (MIP)-chemiluminescence (CL) method has been developed for detection of proline. The molecularly imprinted polymer microspheres were synthesized using precipitation polymerization with hydroxyproline, a structural analogue, as the template. Polymer microspheres were immobilized in microtiter plates (96 wells) which selectively adsorbed the analyte (dansyl-proline). After washing, the bound fraction was quantified based on peroxyoxalate chemiluminescence (PO-CL) reaction enhanced by imidazole. The cavity of MIP synthesized with hydroxyproline as template is smaller, which can avoid non-specific adsorption and lead to enhancement of specificity, response speed and sensitivity when recognizing dansyl-proline. Under the optimum conditions, the relative CL intensity has a linear relationship with the concentration of proline in the range of 1 x 10-6 mol L-1 to 4 x 10-5 mol L-1, with a limit of detection 3 x 10-7 mol L-1 (3σ). The relative standard deviation (R.S.D.) for proline (1x 10-6 mol L-1, n = 7) was 3.7%. The MIP-CL method can become a useful analytical technology for determination of proline in real sample
Template and target information: proline, dansyl-proline
Author keywords: molecularly imprinted polymer, chemiluminescence, array sensor, Proline, precipitation polymerization


  mipdatabase.com logo special offer joke shirt  Lab Heroine Periodic bag  HE-MAN polymer chemistry shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner